Antineoplastic drugs

Most antineoplastic agents are categorized according to their structure or cell cycle activity - either cell cycle phase specific or cell cycle phase non-specific.

Cell cycle phase specific agents act on the cells in a particular phase. They are most active against tumours that have a huge proportion of cells vigorously moving through the cell cycle and cycling at a fast rate. Fast cycling ensures that the cell passes through the phase in which it is susceptible to the drugs' effects.

Generally, they are categorized as

(1)alkylating agents,

 (2) antimetabolites,

(3) natural products,

 (4) hormones and antagonists,

 (5) miscellaneous.

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