21^st World Congress on Radiology & Cancer Research Aug 27-28, 2018 Toronto, Ontario, Canada

Mosa Alhamami earned his PhD from the University of Toronto for his work on manganese-enhanced MRI of breast cancers. His research was recognized with more than $130,000 of scholarships from local and federal funding sources and was nominated to represent the University of Toronto at the national competition for the Vanier Canada Graduate Scholarship and the provincial competition for the Ontario Women’s Health Scholars Award. Since July 2016, Dr Alhamami has been a Scientific Reviewer for the Journal of Magnetic Resonance Imaging and was recognized by the International Society for Magnetic Resonance in Medicine for his service to the journal.

 

Carlos Zepeda-Velázquez earned his BSc degree in Pharmaceutical Chemistry from La Salle University and his M.Sc. in Organic Chemistry from National Autonomous University of Mexico in 2003 and 2006 respectively. Subsequently, he worked as a process chemist at Signa, SA de CV (Apotex Pharmachem INC). For his doctoral studies he moved to Canada in 2009 and joined the group of Dr McNulty at McMaster University where he completed the total synthesis of the anticancer natural product (+)-trans-Dihydrolycoricidine. He then moved to the Ontario Institute for Cancer Research under Dr Rima Al-awar, working on novel anti-tumor agents and in 2016 he was promoted to Research Scientist. His research focuses on chemical biology of chromatin regulation and drug discovery.

 

Oral cavity malignancies are very highly prevalent in the Indian Subcontinent and in recent times T1 and T2 disease have become the common presentation. Upfront surgery with neck node clearance is the management of choice, however, we aim to prevent the morbidity of nodal clearance if we can prove the absence of nodal disease in the neck preoperatively. We studied 30 patients with oral malignancies who underwent surgery as primary treatment. A total of 127 lymph nodes were identified on MRI and correlated with Histopathology for the presence of metastasis. Our analysis of these nodes showed that using RECIST criteria of short axis >10 mm, has a sensitivity and specificity was 35% and 89% respectively. Thus we studied other imaging parameters that when used in combination would have a better predictive value. STIR proved to be very highly sensitive in detecting the presence of a lymph node while Extracapsular invasion, Rim enhancement, and T2 heterogeneity are highly specific for metastatic involvement. Thus a combination of STIR and any one of the specific findings provides a high Sensitivity and Negative predictive value with a reasonable Specificity which could preclude a neck dissection in c N0 patients. Diffusion studies revealed lower mean ADC in malignant nodes, however, it was not statistically significant to identify metastatic disease in subcentimeter nodes in the neck

 

Goal: The aim of this work shop is to prepare pediatric health care workers (HCW) to effectively conceptualize & define concepts of end of life care, identify the child’s clinical status, utilize effective methods of communications and interactions maintain a multidisciplinary approach, ascertain the child and family’s medical and psycho-social needs, execute a formulated plan and take post death steps as an ideal HCW Background: Over the last several years, advancements in medical care of complicated medical conditions like cancers and multi-organ failure syndromes as well as general public awareness of the basic disease processes has placed emphasis on medical community to be more efficient and be prepared to make correct transition from cure to end of life care when appropriate time comes. Overall, there is a gap among HCW’s comprehension, assimilation and swift formulation of line of action regarding realizing the needs of the patients who are approaching end stages of their diseases and as well as of their families. Summary of Learning Objectives: This novel envisioned workshop shall gear the participants to learn and practice the following: 1. Use objective methods to formulate a check list regarding patient’s current medical status 2. Use effective methods of communication to approach patients and their families 3. Identify the medical needs of the patients regarding end of life care 4. Identify medico-legal role of HCW in assistance of post death proceedings

 

Our research indicated that optimal dose of Vitamin D3 has following 10 unique beneficial effects: 1) significant Anti-cancer effects without side effects, 2) marked decrease in DNA mutation which is proportional to the decrease in 8-OH-dG, 3) marked urinary excretion of Viruses, Bacteria, Fungi, single-cell parasites, & Toxic substances, including Asbestos & metals such as Hg, Pb, & Al, 4) marked increase in Acetylcholine in the brain & the rest of the body, 5) marked increase in DHEA, 6) marked decrease in β-Amyloid (1-42) in brain, 7) marked decrease in Cardiac Troponin I, 8) marked increase in Thymosin α1 (which has natural, powerful, anti-cancer effects & anti-inflammatory effects and enhanced immune system, 9) Thymosin β4 (which has significant improvement in circulatory system), & 10) anti-allergic effects. Although it is well-known that in uterus cancer, ovarian cancer, & breast cancer, Human Papilloma Virus-Type 16 (HPV-16) is involved. We found almost every cancer tissue has HPV-16 infection. In addition, some of the rapidly developed cancer patients, often find mixed co-existing infections of HPV-16, single-cell parasite Toxoplasma Gondii. Our recent research indicated that almost every part of single-cell parasite Toxoplasma Gondii’s cell has a viral infection of Human Herpes Virus-Type 8 (HHV-8). Therefore, most cancer patients have viral infection of HPV-16 with HHV-8. These infections are for some reason about almost same ratio of weight. When the degree of these infections are very high, in presence of other co-existing cancer-promoting factors, cancer can develop very rapidly. Among these important contributing co-existing cancer-promoting factors are repeated exposure of electromagnetic field (EMF), foods & drinks with undesirable contributing factors, harmful underwear, toxic substances or decorations directly touching the skin. Based on the analysis of these problems, we also found most of the eggs from chickens are also infected with HPV-16 & Toxoplasma Gondii with HHV-8. However, these infections only exist at egg yolk and egg white does not have these viral infections. In order to solve these problems, most safe & practical way we develop new method of treating various cancers by the combination of the following 4 methods: 1) Individualized optimal dose of Vitamin D3 using its 10 unique, beneficial effects, 2) Selective drug uptake enhancement method, 3) Manual stimulation of Thymus gland or its representation areas on the back of the hand, & 4) Identification & removal of co-existing major cancer-promoting factors. For example, in the early stage of cancer, when Integrin α5β1 as well as Oncogene CfosAb2 are always increased. In the early stage of cancer when Integrin α5β1 becomes increased about close to 200ng, standard laboratory tests can often confirm presence of cancer using the MRI or other imaging techniques. We use 8-OH-dG to evaluate the aggressiveness of the cancer. Usually, in early stage of cancer, it is 2.5ng. 8-OH-dG is proportional to DNA mutation. DNA mutation is necessary in order for cancer cells to grow. When patient’s condition is advanced & terminal stage, Integrin α5β1 is usually over 1500ng, with metastasis & 8-OHdG becomes 60~80ng or higher. In these patients, when we give individually determined optimal dose of Vitamin D3, for example, Integrin α5β1 of over 1500ng becomes 0.002~0.004ng within 30 minutes after taking individualized optimal dose of Vitamin D3. 8-OH-dG of 60~80ng or higher often reduces to 0.2ng which is within normal range. This significant reduction cannot be compared with many existing standard cancer treatments. Average effective duration of optimal dose of Vitamin D3 is about 8 hours. Therefore, the beneficial effects last average of about 8 hours and you have to take optimal dose every 8 hours. If room temperature is very high, effective time duration reduces to 6~7 hours. If more than 200~300mg of Vitamin C is taken, effect of Vitamin D3 will be completely cancelled. Any food or drink containing large amount of Vitamin C or a fruit with Vitamin C such as lemon juice or orange juice should be avoided. One optimal dose of Vitamin D3 also improves Acetylcholine in the brain & rest of the body. As a result, brain function including memory, concentration, & motor function improves very significantly, particularly for those who have low Acetylcholine levels of 1ng or less. Very strong infection of HPV-16 & HHV-8 markedly reduces from body from over 7000ng to safe range of 500~300ng and large amount of viruses are excreted in urine. Urinary excretion of each virus often increases to 2000~3000ng. Cardiac Troponin I significantly reduces toward normal value due to improvement of cardiovascular circulatory system. In order for optimal dose of Vitamin D3 to reach pathological organ selectively, the author discovered selective drug uptake enhancement method more than 15 years ago by manually stimulating accurate organ representation areas of the hand. In order to make immune system very active, manual stimulation of Thymus gland or its representation areas, particularly at the back of the hand which author discovered in 2017. This makes it the safest treatment without side effects but there are always multiple, major co-existing, cancer-promoting factors. Therefore, our treatment includes identification of major co-existing cancer-contributing factors & removing them. By taking optimal dose of Vitamin D3, both Thymosin α1 & Thymosin β4 increase significantly but additional stimulation of Thymus gland representation area, both Thymosins can reach over 100~150ng from normal value of 5~10ng which enhances both improvements in circulation as well as significantly enhanced immune system