21^st World Congress on Radiology & Cancer Research Aug 27-28, 2018 Toronto, Ontario, Canada

Biography:

For the past 37 years, Dr Szewczuk is Full Professor of Immunology and Medicine at Queen’s University, Kingston, ON Canada. Prior to Queen’s, he was Professor of Mucosal Immunology and Pathology at McMaster University, Hamilton, ON, Canada. He did his Postdoctoral training in cellular immunology at Cornell University Medical College, New York city, USA. Dr Szewczuk’s recent research has focused on the role of glycosylation in receptor activation with a particular focus of TOLL-like, nerve growth factor Trk, EGFR and insulin receptors. He has discovered a novel receptor-signaling platform and its targeted translation in multistage tumorigenesis

Abstract:

Stromal cells and growth factors play important roles during tumor initiation and progression. Growth factors not only mediate normal biological processes such as development and tissue repair but also tumorigenesis by contributing to proliferation and transformation in neoplastic cells. This study investigated the host angiogenic and pro-inflammatory cytokines during tumor initiation and progression in heterotopic xenografts of eGFP-MIAPaCa-2 tumors growing in RAGxCγ double mutant mice. The time-to-tumor progression revealed significant host cytokine responses initiated by the cancer cells in order for them to establish neo-vasculature for tumor growth. Here, cancer cells maneuver multiple hosts circulating angiogenic and pro-inflammatory cytokines by significantly reducing host angiostatic and pro-inflammatory cytokines that restrain tumor development and increasing those that are needed. Oseltamivir phosphate (OP) monotherapy when tumor volume reached 100-200mm3 revealed a reversal in some of the anti-angiogenic and pro-inflammatory cytokines in preventing tumor growth. The data signify several important cytokines as potential biomarkers for therapy. The findings identify for the first time how cancer cells surreptitiously use multiple host cytokines for tumor initiation and progression, all of which can be targeted by OP monotherapy

Biography:

Rola Shaheen, Medical Director and Chief of Radiology at Peterborough Regional Health Center in Ontario- Canada. She serves as provincial lead for Mammography Quality Management Program in partnership with Cancer Care Ontario and College of Physicians and Surgeons of Ontario and Regional Breast Imaging Lead for Mississauga- Halton Central West Region in OBSP. Previously she worked at SEHA in Abu Dhabi as lead breast imaging radiologist and chief of women’s imaging at Mafraq hospital. Graduated from Faculty of Medicine of Jordan University and completed radiology residency at University of Toronto. Completed women’s imaging fellowship at BIDMC-teaching hospital of Harvard Medical School.

Abstract:

Breast imaging practice is one of the most complex yet inetersting practices in any radiology department. Complexity stems from the fact that breast imaging is highly regulated specialty with key indicators meaurements in addition to the essential need for utilization of multi-modality equipments and image guided interventions to accurately establist the diagnosis of breast cancer and plan management accordingly. Providing high quality performance in breast imaging regradless of the setting is crucial to avoid any delay in diagnosis of breast cancer and equally important to is avoid unnecessary furher imaging or interventions to minimize patients’ anxiety and to enusre cost effectiveness. The knots and bolts for successful breast imaging practice include clear understanding of the highly regulated specialty in light of the collaborative multidisciplinary commitment. This talk will focus on providing an understanding of the multifaceted breast imaging practice of screening, diagnostic and interventions, and how the multimodality equipments (digital mammography, tomosynthesis, ultrasound & MRI) can serve realistically in each setting, in an effort to provide a high quality pateint centric, and cost effective practice. Pearls and pifalls will also be presented to help radiologists in every day breast practice.

Biography:

Hussien is an American board certified radiologist. He has graduated from Cairo University Medical School. He also had his radiology residency in Egypt. He finished a four years of radiology fellowships in the University of Rochester in Neuroradiology, Body imaging and women’s imaging. He practiced women’s imaging for about 5 years, four of them at the University of Rochester. During which he was able to successfully make a great change in breast cancer detection rate in one of the affiliated locations in the town of Canandaigua. He then moved to SUNY Upstate Medical University for a wider scope of neuroradiology practice and research. 

Abstract: