Day 1 :
Keynote Forum
Wassil Nowicky
Ukrainian Anti-Cancer Institute, Austria
Keynote: Immune modulating properties of NSC-70 (UKRAIN/NSC-631570)
Biography:
Dr. Wassil Nowicky — Dipl. Ing., Dr. techn., DDDr. h. c., Director of “Nowicky Pharma” and President of the Ukrainian Anti-Cancer Institute (Vienna, Austria). Has finished his study at the Radiotechnical Faculty of the Technical University of Lviv (Ukraine) with the end of 1955 with graduation to “Diplomingeniueur” in 1960 which title was nostrificated in Austria in 1975. Inventor of the anticancer preparation on basis of celandine alkaloids “NSC-631570”. Author of over 300 scientific articles dedicated to cancer research. Dr. Wassil Nowicky is a real member of the New York Academy of Sciences, member of the European Union for applied immunology and of the American Association for scientific progress, honorary doctor of the Janka Kupala University in Hrodno, doctor “honoris causa” of the Open international university on complex medicine in Colombo, honorary member of the Austrian Society of a name od Albert Schweizer. He has received the award for merits of National guild of pharmasists of America. the award of Austrian Society of sanitary, hygiene and public health services and others.
Abstract:
I n a controlled clinical study conducted at the University Grodno (Grodno, Belarus), after the therapy with NSC 631570 the hardening of the tumor, a slight increase in the tumor size (5-10%) and proliferation of connective tissues were observed. The T4/T8 lymphocytes ratio increased by 30%. The tumours appeared harder and slightly enlarged after NSC 631570 therapy, and were easier to detect by ultrasound or radiological examination. Metastatic lymph nodes were also hardened and sclerotic (fibrous). Tumours and metastatic lymph nodes were clearly demarcated from healthy tissue and therefore easier to remove. Complications such as prolonged lymphorrhoea (leakage of lymph onto the skin surface), skin necrosis (death of skin tissue), suppuration of the wound, and pneumonia, all occurred in patients from the two NSC 631570 groups at only half the rate that they appeared in patients from the control group. Based on the results of this study the scientists from Grodno recommended the use of NSC 631570, at the higher dosage, in all breast cancer operations (54, 68-70, 114). Other parameters were also evaluated, e.g. hormones (T3, T4, cortisol, progesterone, estradiol, prolactin; 71), immune values (lymphocytes, immune globulins, complement, phagocytic activity; 72), morphologic and cytochemical changes (73, 110), amino acids and their derivates in plasma (74, 109) and in the tumor tissue (75). In a series of articles the researchers have studied the effect of NSC 631570 on various parameters in breast cancer patients (157-160). Best results were achieved with higher dosage of NSC 631570. Almost every patient noted the improvement of the general well-being, sleep and appetite. During the surgery, the tumors as well as involved lymph nodes were presented sclerotic and well demarcated from the surrounding tissue. This alleviated the surgical removal of the tumor considerably (158). In the tumor tissue, increased concentration of the amino acid proline was revealed indicating augmented production of connective tissue that demarcates the tumor from surrounding tissue (159). NSC 631570 improved also the amino acid balance of patients (160). A recent in vitro study with murine and human cancer cell lines confirmed these good results in the treatment of breast cancer were not accidental. The researches from Emory University (Atlanta, Georgia, USA) and Kennesaw State University (Kennesaw, Georgia, USA) concluded: “The anticancer drug Ukrain experts its cytotoxic effects on both mouse and human breast cancer cell lines in a dose and time dependent manner. Weeks following Ukraine treatment, cells maintained a reduced capacity to proliferate. Our data suggest that Ukraine could be effective as an anticancer drug for breast cancer due to its short term and long term inhibitory effects on tumor cell viability and proliferation” (268). This work was supported by RO1 CA-138993 and the NSF Award #0450303 Subaward #1- 66-606-63. The National Science Foundation (NSF) is an independent federal agency created by the US Congress in 1950 “to promote the progress of science, to advance the national health, prosperity, and welfare, to secure the national defense…” With an annual budget about $6,9 billion (FY 2010), NSF is the funding source for approximately 20 percent of all federally supported basic research conducted by America`s colleges and universities..
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Chair
session1
Session Introduction
Berg B
University Hospital of Basel, Switzerland
Title: Medication related osteonecrosis of the jaw (MRONJ): computer assisted assessment of pathological skeletal changes
Time : 9:30: 10:00
Biography:
Berg B I has compelted her Medical degree at the University of Lübeck and her Dental degree at the Universiy of Freiburg, Germany. Since 2005, she works at the Clinic of Cranio- Maxillofacial Surgery at the University Hospital Basel, Switzerland. Currently, she is in charge of the Dentomaxillofacial Radiology at the Universiy Hospital Basel. In between, she worked in Great Britain (Eastbourne, Brighton), France (Paris) and the United States (New York City). She has authored/co-authored over 20 papers. She has presented over 30 lectures herself and was co-author in over 50 other presentations (national and international).
Abstract:
Medication related pathological changes in mandibular bone due to oncologic treatment are a serious burden. Clear display of the progression of the disease is still a challenge in clinical diagnosis. Therefore, a detailed research project focused on CT-/CBCT-based visualization of necrotic changes was initiated. To start with, all available CT-/CBCT data of the patient are registered on a suitable reference. After several refined image processing and programming steps, the data are subjected to slice oriented direct volume rendering with various (mostly logarithmic) transfer functions specially designed for the respective purpose. For medication related pathological changes, besides destructive skeletal changes, severe sclerosing processes within trabecular structure are reported. Destructive processes correspond to decreased Hounsfield values, whereas sclerosation is indicated by increasing ones. For this purpose, we refer to visualization based on an “inverted temperature color scale”. As kind of control, visualization based on healthy subjects can be considered. Additionally, we compare the affected and the non-affected (or less affected) mandibular side. For healthy controls, the new method provides a clear and uniform appearance of the alveolar ridge. However, for pathological cases, serious changes in trabecular bone are ipsilaterally reported. Considering several follow-up CT data, progression of the described changes over the whole mandible was observed. Recent achievements for computer assisted visualization for necrotic changes in mandibular bone are presented. Besides diagnostic significance, this research is aimed at diagnosis efficiency. The new visualization methods help the surgeon to examine the pathological changes at one glanceMedication related pathological changes in mandibular bone due to oncologic treatment are a serious burden. Clear display of the progression of the disease is still a challenge in clinical diagnosis. Therefore, a detailed research project focused on CT-/CBCT-based visualization of necrotic changes was initiated. To start with, all available CT-/CBCT data of the patient are registered on a suitable reference. After several refined image processing and programming steps, the data are subjected to slice oriented direct volume rendering with various (mostly logarithmic) transfer functions specially designed for the respective purpose. For medication related pathological changes, besides destructive skeletal changes, severe sclerosing processes within trabecular structure are reported. Destructive processes correspond to decreased Hounsfield values, whereas sclerosation is indicated by increasing ones. For this purpose, we refer to visualization based on an “inverted temperature color scale”. As kind of control, visualization based on healthy subjects can be considered. Additionally, we compare the affected and the non-affected (or less affected) mandibular side. For healthy controls, the new method provides a clear and uniform appearance of the alveolar ridge. However, for pathological cases, serious changes in trabecular bone are ipsilaterally reported. Considering several follow-up CT data, progression of the described changes over the whole mandible was observed. Recent achievements for computer assisted visualization for necrotic changes in mandibular bone are presented. Besides diagnostic significance, this research is aimed at diagnosis efficiency. The new visualization methods help the surgeon to examine the pathological changes at one glance
Dawn McDonald
James Paget Hospital, UK
Title: The Toshiba Aplio 400 is a key component in a small local study investigating the potential suitability of elastography in differentiating between benign and malignant breast pathology, its objective to determine a numerical figure that may be significant in aiding the judgement call between benign and malignant lesions
Biography:
Dawn McDonald completed her MSc in Medical Imaging, from Kingston University in 2008, and became a Consultant Mammographer soon afterwards. Working with the same autonomy and professionalism as a Consultant Breast Radiologist, she is responsible for all aspects of breast diagnosis within her unit, including breast interventional and film reading, and works closely with the surgical team. Currently, she is working at the James Paget Hospital in Great Yarmouth UK, and Imperial College London
Abstract:
Benign breast disease is common among women and when symptomatic, surgical management is the preferred option for both clinicians and patients alike (Lakoma and Eugene, 2014). Elastography is a relatively new tool, which still appears to be little utilised in breast imaging. Its use, when applied in the clinical setting, can differentiate between benign and malignant pathology, in particular focal lesions. But how useful is this? And if useful, is it possible to arrive at a numerical value which may determine whether a lesion is likely to be benign or not? A small local study undertaken over one year has suggested that elastography is indeed useful clinically, and that it is possible to arrive at a numerical value which can be significant in differentiating between benign and malignant lesions, as long as it is used in conjunction with other modalities such as mammography and ultrasound. Age is also key factor to be taken account of in the analysis.
Implementation of the technique outlined by this study could significantly reduce the numbers of benign breast biopsy undertaken, resulting in substantially lower financial costs for the medical services, and reducing the number of women suffering the anxiety of unnecessary procedures ultimately leading to benign outcomes
Slobodan Marinković
Belgrade University Faculty of Medicine, Belgrade, Serbia
Title: Radiologic study of the craniovertebral malformations in pituitary duplication
Biography:
Slobodan Marinković has completed his PhD at the age of 31 years at Belgrade University and postdoctoral studies at the Laboratory of Neurophysiology, Panum Institute in Copenhagen (Denmark). He has published 2 international books, four chapters in 2 other books, 8 national books, more than 60 papers in reputed journals and has been serving as an editorial board member of repute. He has about 1 200 citations in international publications. He has given 16 lectures at various international congresses and universities as an invited speaker and has been a chairman person on three occasions
Abstract:
Some congenital malformations are so rare that any new case should be described in detail. We had the opportunity to examine a patient with the hypogonadism, obesity, and some limitation of the neck rotation. The T1-weighted magnetic resonance imaging (MRI) of the brain showed two pituitary glands, each of them with its own pituitary stalk. In addition, the region of the median eminence, i.e. the posterior part of the tuber cinereum and infundibulum, was thicker than usual and was fused with the mammillary bodies. Just left to the fusion, a small suprasellar hamartoma was noticed. The multislice computerized tomography (MSCT) presented a double hypophyseal fossa, the posterior clinoid process, the odontoid process and the axis body, as well as a broad clivus, an inverse foramen magnum, the third occipital condyle, a foramen transversarium defect, a partial agenesis of the anterior and posterior atlas arches, and a fusion of the first four cervical vertebrae. The third condyle measured 12.9 mm × 10.8 mm. The gap between the right and left remnants of the anterior arch measured 22.7 mm, and the missing middle part of the posterior arch had a transverse diameter of 26.1 mm. The right and left odontoid processes were 7.7 mm and 8.6 mm in height, respectively, and the cleft between their apical parts measured 3.7 mm in the transverse direction. Since our patient is one of only 40 reported individuals with a pituitary duplication in the last 150 years, the case description is of a great scientific and clinical significance.
Zoya Vinokur
New York City College of Technology, USA
Title: A study of cultural competence and implicit bias amongst healthcare students
Biography:
Professor Zoya Vinokur is an alumn of New York City College of Technology. Professor Vinokur teaches Radiographic Procedures and Clinical Education. She received her Bachelor of Science degree from Long Island University, C.W. Post, her Master of Science degree in Health Services Management and Policy from New School University and holds advanced certification in mammography. With over 20 years of professional and teaching experience she has taught a variety of courses in the medical imaging discipline including, Radiographic Procedures and Positioning, Pediatric Radiography, Advanced Medical Imaging II in a baccalaureate degree program, and Clinical Education. Professor Vinokur worked in major Metropolitan Hospitals in New York and New Jersey she brings her extensive knowledge and background to the classroom as well as in to clinical settings. She is licensed to practice in both New York and New Jersey States
Abstract:
Cultural competence is defined as the ability of providers and organizations to effectively deliver equitable and unbiased health care that meet the social, cultural, and linguistic needs of a culturally diverse patient body. By 2050, minority populations will increase to 48 percent of the US population and Hispanics will represent 24.4 percent of the total population (US Census, 2010). This demographic shift brings challenges and opportunities to universities and organizations alike to create policies and curriculums that foster quality health care amongst students, while also contributing to the eradication of implicit biases that may unwittingly perpetuate healthcare disparities amongst racial and ethnic minority groups. Our research looks to answer the critical question of whether health care students are adequately prepared by their universities to deliver healthcare services that are culturally competent and sensitive? Are students aware of the importance of implicit biases and what measures can be taken on an institutional level to ensure that healthcare students are adequately prepared to deliver equitable healthcare to all minority groups? This study looks to gauge the understanding of cultural competence amongst a group of City Tech healthcare students by utilizing a cross-cultural survey of cultural competence questions dealing with poverty, age, stereotypes, illiteracy, homophobia, language, religion, and racism. Our data and research results suggest that many health care students are not able to properly define, nor fully implement cultural competence and sensitivity in their clinical settings. This data is significant because administrators and educators need to incorporate more learning strategies and relevant clinical training so that students may enter the work force better equipped to deliver the highest quality of care to all patients, regardless of race, ethnicity, cultural background, English proficiency or literacy