Sang Y Lee
North Hampshire Hospital, UK
Title: Temozolomide resistance in glioblastoma multiforme and its application for drug development
Biography
Biography: Sang Y Lee
Abstract
Gliomas account for 28% of all primary brain and central nervous system (CNS) tumors, and 80% of them are malignant. Among gliomas, glioblastoma multiforme (GBM) is the most common malignant type. The median survival time for GBM patients is 14.6 months. The 2 year survival rate of GBM patients is just 10.4% for those treated with radiotherapy alone and 26.5% for patients treated with both chemotherapy, temozolomide (TMZ), and radiation. The current chemotherapeutic standard for GBM is TMZ - an oral alkylating agent. However, at least 50% of TMZ treated patients do not respond to TMZ. This is due primarily to the over-expression of O6-methylguanine methyltransferase (MGMT) and/or lack of a DNA repair pathway in GBM cells. Multiple GBM cell lines are known to contain TMZ resistant cells and several acquired TMZ resistant GBM cell lines have been developed for use in experiments designed to define the mechanism of TMZ resistance and the testing of potential therapeutics. The characteristics of intrinsic and adaptive TMZ resistant GBM cells, however, have not been systemically compared. In this presentation, I will i) compare the characteristics and mechanisms of TMZ resistance in natural and adapted TMZ resistant GBM cell lines, ii) summarizes potential treatment options for TMZ resistant GBMs, and iii) drug development using TMZ resistant cells.